Isotopically Labeled Compounds
Medchemexpress LLC Serotonin-d4 | 58264-95-2 | MFCD21363848 | >99.35% | 5 MG
Serotonin-d4 is deuterium labeled Serotonin. Serotonin is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. It is also a catechol O-methyltransferase (COMT) inhibitor with a Ki of 44 μM.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Medchemexpress LLC Corticosterone-d8 | 1271728-07-4 | 99.91% | 5 MG
Corticosterone-d8 is the deuterium-labeled Corticosterone. Corticosterone is an adrenocortical steroid that exhibits modest but significant activities as both a mineralocorticoid and a glucocorticoid. The incorporation of stable heavy isotopes like deuterium into drug molecules is primarily for quantitation during drug development, with deuteration specifically recognized for its potential impact on the pharmacokinetic and metabolic profiles of drugs.
- Used as a tracer
- Used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC Amitraz-d3 | 33089-61-1 | 99.5% | 1 MG
Amitraz-d3 is a deuterium-labeled version of Amitraz, a non-systemic acaricide and insecticide. Amitraz functions as an alpha-adrenergic agonist, interacts with octopamine receptors in the central nervous system, and inhibits monoamine oxidases and prostaglandin synthesis. This compound is intended for research purposes.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Stable heavy isotopes are incorporated into drug molecules for quantitation during drug development.
- Deuteration may affect the pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC DC-LC3in-D5 | 2868312-73-4 | 98.6% | C19H22Cl2N2O3 | 10 MM 1 ML
DC-LC3in-D5 is an autophagy inhibitor that functions by attenuating LC3B lipidation. It binds with LC3B and disrupts the LC3B-LBP2 interaction with an IC50 of 200 nM. This compound may be useful in anti-HCV or combination cancer research through its autophagy-inhibiting properties.
- Attenuates LC3B lipidation
- Disrupts LC3B-LBP2 interaction
- Demonstrates high selectivity to LC3A/B in proteome
- Exhibits potent covalent reactivity and selectivity to LC3A/B in HeLa cells
- Inhibits autophagic vesicle formation
- Leads to accumulation of p62
Medchemexpress LLC Uridine-13C | 201996-62-5 | 99.8% | 1 MG
Uridine-13C is the 13C labeled Uridine. It is used as a tracer and an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS. Stable heavy isotopes of hydrogen, carbon, and other elements are incorporated into drug molecules primarily as tracers for quantitation during the drug development process.
- Used as a tracer
- Functions as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Incorporates stable heavy isotopes of hydrogen, carbon, and other elements
- Potential to affect pharmacokinetic and metabolic profiles of drugs through deuteration
Medchemexpress LLC Lactate-d4 sodium | 344299-52-1 | 99.0% | 5 MG
Lactic acid-d4 sodium (60% in water) is a deuterium-labeled form of lactic acid sodium. The unlabeled compound is a hydroxycarboxylic acid receptor 1 (HCAR1) activator and an epigenetic modulator that induces lysine residue lactylation. It serves as a glycolysis end-product, bridging glycolysis and oxidative phosphorylation. It is also recognized as an oncometabolite with an immune-protective role in anti-tumor immunity and possesses antimicrobial activity, making it suitable as a food preservative.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Stable heavy isotopes have been incorporated into drug molecules for quantitation during drug development.
- Deuteration has potential to affect pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC Stearic acid-d5 | 211443-83-3 | 5 MG
Stearic acid-d5 is a deuterium labeled stearic acid, which is a long-chain dietary saturated fatty acid found in many animal and vegetable fats and oils. It is used as a tracer for quantitation in drug development, with deuteration potentially affecting pharmacokinetic and metabolic profiles of drugs.
- Deuterium labeled stearic acid
- Used as a tracer for quantitation in drug development
- Potential to affect pharmacokinetic and metabolic profiles of drugs
- Store powder at -20°C for 3 years, or 4°C for 2 years
- Store in solvent at -80°C for 6 months, or -20°C for 1 month
Medchemexpress LLC L-Ascorbic acid-13C | 178101-88-7 | 99.9% | 1 MG
L-Ascorbic acid-13C is the 13C-labeled L-Ascorbic acid, an electron donor, and an endogenous antioxidant agent. It selectively inhibits Cav3.2 channels, enhances collagen deposition, and inhibits elastogenesis. This compound also exhibits anti-cancer effects by generating reactive oxygen species (ROS) and selectively damaging cancer cells.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Incorporates stable heavy isotopes for quantitation during drug development.
- Selectively inhibits Cav3.2 channels with an IC50 of 6.5 μM.
- Enhances collagen deposition and inhibits elastogenesis.
Medchemexpress LLC Flubendazole-d3 | 1173021-08-3 | 96.00% | 1 MG
Flubendazole-d3 is a deuterium-labeled version of Flubendazole, a safe and effective anthelmintic agent used in humans, rodents, and ruminants. It demonstrates anticancer activities by inhibiting microtubule function, inducing p53-mediated apoptosis, and arresting the G2/M cell cycle. Deuterium substitution in drug molecules can impact their pharmacokinetic and metabolic profiles.
- Deuterium labeled version of Flubendazole
- Safe and effective anthelmintic agent
- Exhibits anticancer activities via microtubule inhibition
- Induces p53-mediated apoptosis
- Arrests G2/M cell cycle
- Can be used as a tracer
- Serves as an internal standard for quantitative analysis (e.g., NMR, GC-MS, LC-MS)
Medchemexpress LLC Adenosine-d | 109923-50-4 | 100.0% | 5 MG
Adenosine-d | 109923-50-4 | 100.0% | 5 MG
Cayman Chemical DL-AspartIcAcId-d3 100mg
An internal standard for the quantification of aspartic acid by GC- or LC-MS
Cayman Chemical SalvInorIn A-d3 1mg
An internal standard for the quantification of salvinorin A by GC- or LC-MS; intended for research and forensic applications
Medchemexpress LLC Teriflunomide-d4 | 1185240-22-5 | 99.98% | 274.23 | 50 MG
Teriflunomide-d4 is deuterium labeled Teriflunomide. It is intended for research use only and is not sold to patients.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.